(19)

(11)

EP 0 929 218 A2

(12)

(43) Date of publication: 21.07.1999 Bulletin 1999/29 (21) Application number: 97952172.0 (22) Date of filing: 23.10.1997

(51) International Patent Classification (IPC):  G01N 33/ 566( . ) A61K 31/ 7076( . ) A61P 9/ 08( . ) A61P 43/ 00( . ) C07H 19/ 16( . ) A61K 31/ 7072( . ) A61P 5/ 00( . ) A61P 13/ 10( . ) C07H 19/ 10( . ) C07H 19/ 20( . ) (86) International application number: PCT/US1997/019922 (87) International publication number: WO 1998/018430 (07.05.1998 Gazette 1998/18)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 30.10.1996 US 19960029855P (71) Applicant: UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL Chapel Hill, NC 27599-4105 (US)	(72) Inventors: BOYER, José, L. Chapel Hill, NC 27516 (US) HARDEN, T., Kendall Chapel Hill, NC 27514 (US) JACOBSON, Kenneth, A. Silver Spring, MD (US) CAMAIONI, Emidio Kensington, MD 20895 (US) (74) Representative: Harrison Goddard Foote  Belmont House, 20 Wood Lane Leeds LS6 2AE Leeds LS6 2AE (GB)