(19)
(11) EP 0 929 301 A2

(12)

(43) Date of publication:
21.07.1999 Bulletin 1999/29

(21) Application number: 97939064.0

(22) Date of filing: 08.09.1997
(51) International Patent Classification (IPC): 
A61K 9/ 22( . )
A61K 9/ 20( . )
A61K 31/ 435( . )
A61K 47/ 10( . )
A61P 25/ 28( . )
A61K 9/ 16( . )
A61K 9/ 50( . )
A61K 31/ 439( . )
A61K 47/ 38( . )
(86) International application number:
PCT/GB1997/002418
(87) International publication number:
WO 1998/010762 (19.03.1998 Gazette 1998/11)
(84) Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
SI

(30) Priority: 12.09.1996 GB 19960019074

(71) Applicants:
  • SMITHKLINE BEECHAM PLC
    Brentford, Middlesex TW8 9EP (GB)
  • SMITHKLINE BEECHAM CORPORATION
    Philadelphia Pennsylvania 19103 (US)

(72) Inventors:
  • MILOSOVICH, Susan, Marie, SmithKline Beecham Phar.
    Collegeville, PA 19426-0989 (US)
  • MULDOON, William, SmithKline Beecham Pharmaceut.
    Collegeville, PA 19426-0989 (US)
  • NAPPER, James Albert, SmithKline Beecham Pharma.
    Harlow, Essex CM19 5AW (GB)
  • ROUSSEAU, Laurence, SmithKline Beecham Pharmaceut.
    Harlow, Essex CM19 5AW (GB)
  • SAUER, Joseph, SmithKline Beecham Pharmaceuticals
    Collegeville, PA 19426-0989 (US)

(74) Representative: Valentine, Jill Barbara, et al 
SmithKline Beecham plc Corporate Intellectual Property, Two New Horizons Court
Brentford, Middlesex TW8 9EP
Brentford, Middlesex TW8 9EP (GB)

   


(54) CONTROLLED RELEASE DOSAGE FORM OF R-(Z)]-ALPHA-(METHOXYIMINO)-ALPHA-(1-AZABICYCLO 2.2.2]OCT-3-YL)ACETONITRILE MONOHYDROCHLORIDE