(19)
(11) EP 0 929 311 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
01.02.2006 Bulletin 2006/05

(45) Mention of the grant of the patent:
23.11.2005 Bulletin 2005/47

(21) Application number: 97943323.2

(22) Date of filing: 12.09.1997
(51) International Patent Classification (IPC): 
A61K 38/00(1995.01)
 C07H 21/00(1974.07)
(86) International application number:
PCT/US1997/016369
(87) International publication number:
WO 1998/010778 (19.03.1998 Gazette 1998/11)

(54)

INHIBITION OF APOPTOSIS USING INTERLEUKIN-1 beta-CONVERTING ENZYME (ICE)/CED-3 FAMILY INHIBITORS

HEMMUNG DER APOPTOSE UNTER VERWENDUNG VON INHIBITOREN DER INTERLEUKIN-1 BETA CONVERTING ENZYM (ICE)/CED-3 FAMILIE

INHIBITION DE L'APOPTOSE AU MOYEN D'INHIBITEURS DE LA FAMILLE CED-3/ICE (ENZYME DE CONVERSION DE L'INTERLEUKINE-1 beta

(84) Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 12.09.1996 US 26011 P
20.09.1996 US 710621
16.12.1996 US 767175

(43) Date of publication of application:
21.07.1999 Bulletin 1999/29

(60) Divisional application:
05025451.5

(73) Proprietor: Idun Pharmaceuticals, Inc.
San Diego, CA 92121 (US)

(72) Inventors:
  • FRITZ, Lawrence, C.
    Rancho Santa Fe, CA 92067 (US)
  • TOMASELLI, Kevin, J.
    San Diego, CA 92103 (US)
  • KARANEWSKY, Donald S.
    Escondido, CA 92029 (US)
  • LINTON, Steven D.
    San Diego, CA 92131 (US)
  • BAI, Xu.
    Carlsbad, CA 92009 (US)

(74) Representative: Gowshall, Jonathan Vallance et al
FORRESTER & BOEHMERT Pettenkoferstrasse 20-22
80336 München
80336 München (DE)


(56) References cited: : 
EP-A- 0 595 610
US-A- 5 514 694
 WO-A-95/05192
   
  • SCIENCE, February 1994, Vol. 263, GAGLIARDINI V. et al., "Prevention of Vertebrate Neuronal Death by the crmA Gene", pages 826-828, XP002013931.
  • CELL, November 1993, Vol. 75, MIURA M. et al., "Induction of Apoptosis in Fibroblasts by IL-1 Beta-Converting Enzyme, a Mammalian Homolog of the C. Elegans Cell Death Gene ced-3", pages 653-660, XP000676423.
  • NATURE, July 1995, Vol. 376, NICHOLSON D.W. et al., "Identification and Inhibition of the ICE/CED-3 Protease Necessary for Mammalian Apoptosis", pages 37-43, XP000574812.
 
Remarks:
The file contains technical information submitted after the application was filed and not included in this specification
 
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).