(19)

(11)

EP 0 929 535 A1

(12)

(43) Date of publication: 21.07.1999 Bulletin 1999/29 (21) Application number: 97941446.0 (22) Date of filing: 05.09.1997

(51) International Patent Classification (IPC):  C07D 273/ 08( . ) C07C 227/ 06( . ) C07C 227/ 18( . ) C07C 229/ 36( . ) C07C 235/ 34( . ) C07D 273/ 00( . ) C07D 291/ 02( . ) C07B 61/ 00( . ) C07C 227/ 16( . ) C07C 229/ 12( . ) C07C 231/ 02( . ) C07C 291/ 02( . ) C07D 273/ 01( . ) (86) International application number: PCT/US1997/015703 (87) International publication number: WO 1998/009955 (12.03.1998 Gazette 1998/10)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 06.09.1996 US 19960025521P (71) Applicants: ELI LILLY AND COMPANY Indianapolis, Indiana 46285 (US) UNIVERSITY OF HAWAII Honolulu, HI 96822 (US) Wayne State University Detroit, Michigan 48202 (US)

(72) Inventors: HUTCHISON, Darrell, R. Indianapolis, IN 46222 (US) JANISSE, Samantha, K. San Jose, CA 95125 (US) MARTINELLI, Michael, J. Zionsville, IN 46007 (US) MOHER, Eric, D. Indianapolis, IN 46237 (US) SULLIVAN, Kevin, A. Greenwood, IN 46142 (US) VARIE, David, L. Indianapolis, IN 46220 (US) HOARD, David, W. Greenwood, IN 46142 (US) TOTH, John, E. Indianapolis, IN 46278 (US) (74) Representative: Hudson, Christopher Mark, et al  Lilly Industries Limited European Patent Operations Erl Wood Manor Windlesham Surrey GU20 6PH Windlesham Surrey GU20 6PH (GB)