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(11)

EP 0 929 575 A1

(12)

(43) Date of publication: 21.07.1999 Bulletin 1999/29 (21) Application number: 97924803.0 (22) Date of filing: 22.08.1997

(51) International Patent Classification (IPC):  C07K 14/ 475( . ) A61K 38/ 00( . ) C12N 1/ 21( . ) (86) International application number: PCT/US1997/014139 (87) International publication number: WO 1998/007749 (26.02.1998 Gazette 1998/08)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 23.08.1996 WO 1996US13766 (71) Applicant: HUMAN GENOME SCIENCES, INC. Rockville, MD 20850-3338 (US)	(72) Inventors: YU, Guo-Liang Darnestown, MD 20878 (US) DILLON, Patrick, J. Carlsbad, CA 92009 (US) EBNER, Reinhard Gaithersburg, MD 20878 (US) ENDRESS, Gregory, A. Potomac, MD 20850 (US) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 81634 München 81634 München (DE)