HISTIDINE-TAGGED SHIGA TOXINS, TOXOIDS, AND PROTEIN FUSIONS WITH SUCH TOXINS AND TOXOIDS, METHODS FOR THE PURIFICATION AND PREPARATION THEREOF - Patent 0929679

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EP 0 929 679 A2

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(43)	Date of publication:
	21.07.1999 Bulletin 1999/29

(21)	Application number: 97939845.0

(22)	Date of filing: 09.09.1997

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International Patent Classification (IPC):

C12N 15/ 09^{( . )}
A61K 39/ 395^{( . )}
A61P 31/ 04^{( . )}
C07K 14/ 245^{( . )}
C07K 16/ 12^{( . )}
C12N 15/ 31^{( . )}

A61K 31/ 711^{( . )}
A61K 48/ 00^{( . )}
C07K 1/ 22^{( . )}
C07K 14/ 25^{( . )}
C12N 1/ 21^{( . )}
A61K 39/ 00^{( . )}

(86)	International application number:
	PCT/US1997/015836

(87)	International publication number:
	WO 1998/011229 (19.03.1998 Gazette 1998/11)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

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Priority:

10.09.1996 US 19960025637P

(71)	Applicant: HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE
	Rockville, MD 20852 (US)

(72)	Inventors:
	O'BRIEN, Alison, D. Bethesda, MD 20817 (US) SCHMITT, Clare, K. Rockville, MD 20853 (US)

(74)	Representative: Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät
	Maximilianstrasse 58 80538 München 80538 München (DE)

(54)	HISTIDINE-TAGGED SHIGA TOXINS, TOXOIDS, AND PROTEIN FUSIONS WITH SUCH TOXINS AND TOXOIDS, METHODS FOR THE PURIFICATION AND PREPARATION THEREOF