ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME - Patent 0932598

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(11)

EP 0 932 598 A1

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(43)	Date of publication:
	04.08.1999 Bulletin 1999/31

(21)	Application number: 97911715.0

(22)	Date of filing: 09.10.1997

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International Patent Classification (IPC):

C07D 233/ 34^{( . )}
A61K 31/ 222^{( . )}
A61K 31/ 343^{( . )}
A61K 31/ 40^{( . )}
A61K 31/ 4164^{( . )}
A61K 31/ 428^{( . )}
A61K 31/ 4409^{( . )}
A61K 31/ 472^{( . )}
A61K 38/ 00^{( . )}
A61P 25/ 28^{( . )}
A61P 31/ 10^{( . )}
C07C 233/ 47^{( . )}
C07C 233/ 51^{( . )}
C07C 275/ 16^{( . )}
C07C 311/ 03^{( . )}
C07C 311/ 19^{( . )}
C07C 317/ 44^{( . )}
C07C 327/ 32^{( . )}
C07D 207/ 16^{( . )}
C07D 207/ 27^{( . )}
C07D 207/ 48^{( . )}
C07D 209/ 18^{( . )}
C07D 211/ 76^{( . )}
C07D 213/ 55^{( . )}
C07D 217/ 24^{( . )}
C07D 233/ 64^{( . )}
C07D 277/ 64^{( . )}
C07D 307/ 79^{( . )}
C07D 333/ 22^{( . )}
C07D 333/ 38^{( . )}
C07D 333/ 60^{( . )}
C07K 5/ 02^{( . )}

A61K 31/ 22^{( . )}
A61K 31/ 341^{( . )}
A61K 31/ 381^{( . )}
A61K 31/ 405^{( . )}
A61K 31/ 4166^{( . )}
A61K 31/ 44^{( . )}
A61K 31/ 4412^{( . )}
A61K 31/ 505^{( . )}
A61P 1/ 00^{( . )}
A61P 29/ 00^{( . )}
A61P 43/ 00^{( . )}
C07C 233/ 50^{( . )}
C07C 271/ 22^{( . )}
C07C 275/ 60^{( . )}
C07C 311/ 06^{( . )}
C07C 317/ 04^{( . )}
C07C 323/ 52^{( . )}
C07D 207/ 08^{( . )}
C07D 207/ 26^{( . )}
C07D 207/ 28^{( . )}
C07D 209/ 08^{( . )}
C07D 211/ 34^{( . )}
C07D 211/ 96^{( . )}
C07D 213/ 75^{( . )}
C07D 233/ 36^{( . )}
C07D 239/ 10^{( . )}
C07D 307/ 68^{( . )}
C07D 307/ 80^{( . )}
C07D 333/ 24^{( . )}
C07D 333/ 54^{( . )}
C07K 5/ 00^{( . )}
C07K 5/ 093^{( . )}

(86)	International application number:
	PCT/US1997/018514

(87)	International publication number:
	WO 1998/016502 (23.04.1998 Gazette 1998/16)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
	Designated Extension States:
	AL LT LV RO SI

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Priority:

11.10.1996 US 19960002832P

(71)	Applicants:
	WARNER-LAMBERT COMPANY Morris Plains New Jersey 07950 (US) BASF AKTIENGESELLSCHAFT 67056 Ludwigshafen (DE)

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Inventors:

ALBRECHT, Hans, P.
D-69517 Gorxheimertal (DE)
ALLEN, Hamish, John
Shrewsbury, MA 01545 (US)
BRADY, Kenneth, Dale
Worcester, MA 01606 (US)
CAPRATHE, Bradley, William
Livonia, MI 48154 (US)
GILMORE, John, Lodge
Ann Arbor, MI 48105 (US)
HARTER, William, Glen
Chelsea, MI 48118 (US)
HAYS, Sheryl, Jeanne
Ann Arbor, MI 48108 (US)
KOSTLAN, Catherine, Rose
Saline, MI 48176 (US)
LUNNEY, Elizabeth, Ann
Ann Arbor, MI 48103 (US)
PARA, Kimberly, Suzanne
Ann Arbor, MI 48103 (US)
THOMAS, Anthony, Jerome
Ann Arbor, MI 48104 (US)
WALKER, Nigel
D-69221 Dossenheim (DE)

(74)	Representative: Mansmann, Ivo
	Warner-Lambert Company, Legal Division, Legal Department, c/o Gödecke AG 79090 Freiburg 79090 Freiburg (DE)

(54)	ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME