3' GENOMIC PROMOTER REGION AND POLYMERASE GENE MUTATIONS RESPONSIBLE FOR ATTENUATION IN VIRUSES OF THE ORDER DESIGNATED MONONEGAVIRALES - Patent 0932684

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EP 0 932 684 A2

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(43)	Date of publication:
	04.08.1999 Bulletin 1999/31

(21)	Application number: 97942613.0

(22)	Date of filing: 19.09.1997

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International Patent Classification (IPC):

C12N 15/ 09^{( . )}
A61K 39/ 155^{( . )}
C07K 14/ 08^{( . )}
C07K 14/ 12^{( . )}
C07K 14/ 145^{( . )}
C12N 7/ 04^{( . )}
C12P 21/ 02^{( . )}

A61K 39/ 00^{( . )}
A61K 39/ 165^{( . )}
C07K 14/ 115^{( . )}
C07K 14/ 135^{( . )}
C12N 7/ 00^{( . )}
C12N 15/ 45^{( . )}

(86)	International application number:
	PCT/US1997/016718

(87)	International publication number:
	WO 1998/013501 (02.04.1998 Gazette 1998/13)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

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Priority:

27.09.1996 US 19960026823P

(60)	Divisional application:
	04018447.5 /

(71)	Applicants:
	AMERICAN CYANAMID COMPANY Madison, New Jersey 07940 (US) THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Rockville, MD 20852-3804 (US)

(72)	Inventors:
	UDEM, Stephen, A. New York, NY 10023 (US) SIDHU, Mohinderjit, S. Highland Mills, NY 10930 (US) TATEM, Joanne, M. Towaco, NJ 07082 (US) MURPHY, Brian, R. Bethesda, MD 20816 (US) RANDOLPH, Valerie, B. Lincoln Park, NJ 07035 (US)

(74)	Representative: Walters, Philip Bernard William, et al
	Wyeth Laboratories, Patents & Trade Marks Department, Huntercombe Lane South, Taplow Maidenhead, Berkshire SL6 0PH Maidenhead, Berkshire SL6 0PH (GB)

(54)	3' GENOMIC PROMOTER REGION AND POLYMERASE GENE MUTATIONS RESPONSIBLE FOR ATTENUATION IN VIRUSES OF THE ORDER DESIGNATED MONONEGAVIRALES