(19)

(11)

EP 0 934 283 A2

(12)

(43) Date of publication: 11.08.1999 Bulletin 1999/32 (21) Application number: 97936152.0 (22) Date of filing: 24.07.1997

(51) International Patent Classification (IPC):  A01N 43/ 653( . ) A01N 43/ 80( . ) A01N 43/ 836( . ) C07D 249/ 12( . ) C07D 401/ 04( . ) C07D 403/ 04( . ) C07D 403/ 12( . ) C07D 405/ 12( . ) C07D 417/ 12( . ) C07F 7/ 08( . ) C07F 7/ 30( . ) A01N 43/ 78( . ) A01N 43/ 82( . ) A01N 43/ 84( . ) C07D 261/ 12( . ) C07D 401/ 12( . ) C07D 403/ 10( . ) C07D 403/ 14( . ) C07D 413/ 12( . ) C07D 417/ 14( . ) C07F 7/ 18( . ) (86) International application number: PCT/US1997/012809 (87) International publication number: WO 1998/005652 (12.02.1998 Gazette 1998/06)

(84) Designated Contracting States: DE FR GB IT (30) Priority: 01.08.1996 US 19960022933P (71) Applicant: E.I. DU PONT DE NEMOURS AND COMPANY Wilmington Delaware 19898 (US)

(72) Inventors: BROWN, Richard, James Newark, DE 19711 (US) CHAN, Dominic, Ming-Tak Wilmington, DE 19803 (US) CLARK, David, Alan Newark, DE 19711 (US) DRUMM, Joseph, Eugene, III Newark, DE 19713 (US) KOETHER, Gerard, Michael Bear, DE 19701 (US) McCANN, Stephen, Frederick Newark, DE 19711 (US) RORER, Morris, Padgett Newark, DE 19711 (US) SELBY, Thomas, Paul Wilmington, DE 19808 (US) WALKER, Michael, Paul Newark, DE 19713 (US) (74) Representative: Woodman, Derek, et al  Frank B. Dehn & Co., European Patent Attorneys, 179 Queen Victoria Street London EC4V 4EL London EC4V 4EL (GB)