(19)

(11)

EP 0 934 313 A1

(12)

(43) Date of publication: 11.08.1999 Bulletin 1999/32 (21) Application number: 97941882.0 (22) Date of filing: 02.10.1997

(51) International Patent Classification (IPC):  A61K 31/ 38( . ) A61K 31/ 445( . ) A61K 31/ 4535( . ) A61P 17/ 04( . ) A61P 29/ 00( . ) C07D 211/ 60( . ) C07D 401/ 06( . ) C07D 409/ 06( . ) A61K 31/ 40( . ) A61K 31/ 4523( . ) A61P 3/ 08( . ) A61P 25/ 06( . ) C07D 207/ 08( . ) C07D 211/ 62( . ) C07D 405/ 06( . ) C07D 417/ 06( . ) (86) International application number: PCT/DK1997/000420 (87) International publication number: WO 1998/015549 (16.04.1998 Gazette 1998/15)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE Designated Extension States: AL LT LV RO SI (30) Priority: 04.10.1996 DK 19960001088 (71) Applicant: NOVO NORDISK A/S 2880 Bagsvaerd (DK)	(72) Inventors: ANDERSEN, Henrik, Sune DK-2100 Copenhagen (DK) JORGENSEN, Tine, Krogh DK-2730 Herlev (DK) HOHLWEG, Rolf DK-3940 Kvistgaard (DK) ANDERSEN, Knud, Erik DK-2765 Smorum (DK) POLIVKA, Zdenek 150 00 Praha 5 (CZ) MIKSIK, Frantisek 149 00 Praha 11 (CZ)