(19)

(11)

EP 0 934 334 A1

(12)

(43) Date of publication: 11.08.1999 Bulletin 1999/32 (21) Application number: 97946247.0 (22) Date of filing: 09.10.1997

(51) International Patent Classification (IPC):  A61K 31/ 565( . ) C07J 1/ 00( . ) A61P 5/ 30( . ) C07J 31/ 00( . ) (86) International application number: PCT/US1997/018306 (87) International publication number: WO 1998/016544 (23.04.1998 Gazette 1998/16)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE Designated Extension States: AL LT LV RO SI (30) Priority: 11.10.1996 US 19960027936P (71) Applicant: AMERICAN HOME PRODUCTS CORPORATION Madison, New Jersey 07940-0874 (US)

(72) Inventors: ADELMAN, Steven, Jay Doylestown, PA 18901 (US) BEX, Frederick, James Newtown Square, PA 19073 (US) CHANDRASEKARAN, Appavu Plainsboro, NJ 08536 (US) PROZIALECK, Dorothy, Helen Holland, PA 18966 (US) WINKLEY, Michael, William Campbell Hall, NY 10916 (US) RAVEENDRANATH, Panolil Monroe, NY 10950 (US) (74) Representative: Connelly, Michael John, et al  c/o Patent Department Wyeth Laboratories Huntercombe Lane South Taplow Maidenhead Berkshire SL6 0PH Maidenhead Berkshire SL6 0PH (GB)