(19)

(11)

EP 0 935 611 A1

(12)

(43) Date of publication: 18.08.1999 Bulletin 1999/33 (21) Application number: 97925197.0 (22) Date of filing: 11.06.1997

(51) International Patent Classification (IPC):  A61K 38/ 55( . ) A61P 43/ 00( . ) C07K 5/ 06( . ) C07K 14/ 81( . ) A61K 38/ 00( . ) A61K 38/ 58( . ) C07K 1/ 10( . ) C07K 5/ 065( . ) C07K 14/ 815( . ) (86) International application number: PCT/GB1997/001574 (87) International publication number: WO 1998/000442 (08.01.1998 Gazette 1998/01)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 29.06.1996 GB 19960013719 (71) Applicant: TRIGEN LIMITED London SW1A 1ES (GB)

(72) Inventors: DEADMAN, John Joseph London NW3 4NG (GB) ELGENDY, Said London NW6 2NT (GB) GREEN, Donovan London E17 6AE (GB) SKORDALAKES, Emmanuel London SE14 5LU (GB) SCULLY, Michael Finbarr Crays Hill, Essex CM11 2XN (GB) GOODWIN, Christopher Andrew Bath, Avon BA2 2SP (GB) KAKKAR, Vijay Vir Warsash, Hants SO3 6HN (GB) (74) Representative: Harrison Goddard Foote  Belmont House, 20 Wood Lane Leeds LS6 2AE Leeds LS6 2AE (GB)