(19)

(11)

EP 0 935 654 A1

(12)

(43) Date of publication: 18.08.1999 Bulletin 1999/33 (21) Application number: 97916166.0 (22) Date of filing: 21.03.1997

(51) International Patent Classification (IPC):  C12N 15/ 02( . ) A61K 31/ 70( . ) A61K 35/ 76( . ) A61K 49/ 00( . ) A61P 25/ 00( . ) A61P 35/ 00( . ) C07K 16/ 22( . ) C12N 1/ 19( . ) C12N 5/ 10( . ) C12N 15/ 12( . ) C12P 21/ 08( . ) A61K 31/ 00( . ) A61K 31/ 7088( . ) A61K 48/ 00( . ) A61K 51/ 00( . ) A61P 25/ 02( . ) C07K 14/ 50( . ) C12N 1/ 15( . ) C12N 1/ 21( . ) C12N 15/ 09( . ) C12P 21/ 02( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1997/004641 (87) International publication number: WO 1997/035007 (25.09.1997 Gazette 1997/41)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 21.03.1996 US 19960621143 (71) Applicant: THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE Baltimore, MD 21205 (US)	(72) Inventors: NATHANS, Jeremy Baltimore, MD 21209 (US) SMALLWOOD, Philip, M. Woodbine, MD 21797-9621 (US) TONG, Patrick Baltimore, MD 21210-1522 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)