(19)

(11)

EP 0 935 662 A2

(12)

(43) Date of publication: 18.08.1999 Bulletin 1999/33 (21) Application number: 97927767.0 (22) Date of filing: 23.05.1997

(51) International Patent Classification (IPC):  G01N 33/ 53( . ) C07K 14/ 18( . ) C12Q 1/ 68( . ) C07K 14/ 155( . ) C12N 15/ 09( . ) G01N 33/ 576( . ) (86) International application number: PCT/US1997/008950 (87) International publication number: WO 1997/044469 (27.11.1997 Gazette 1997/51)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 24.05.1996 US 19960653226 20.05.1997 US 19970859524 (71) Applicant: CHIRON CORPORATION Emeryville, California 94608 (US)	(72) Inventors: VALENZUELA, Pablo, D., T. Berkeley, CA 94705 (US) CHIEN, David, Ying Alamo, CA 94507 (US) (74) Representative: Goldin, Douglas Michael, et al  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)