(4R,5S,6S,7R)-HEXAHYDRO-1- 5-(3-AMINOINAZOLE)METHYL] -3-BUTYL-5,6-DIHYDROXY-4,7-BIS PHENYLMETHYL] -2H-1,3-DIAZEPIN-2-ONE, ITS PREPARATION AND ITS USE AS HIV PROTEASE INHIBITOR - Patent 0937066

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(11)

EP 0 937 066 A1

(12)

(43)	Date of publication:
	25.08.1999 Bulletin 1999/34

(21)	Application number: 97945596.0

(22)	Date of filing: 04.11.1997

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International Patent Classification (IPC):

A61K 31/ 55^{( . )}
A61P 31/ 18^{( . )}

A61K 31/ 551^{( . )}
C07D 403/ 06^{( . )}

(86)	International application number:
	PCT/US1997/020036

(87)	International publication number:
	WO 1998/020009 (14.05.1998 Gazette 1998/19)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

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Priority:

08.11.1996 US 19960747103
08.11.1996 US 19960029746P

(71)	Applicant: Du Pont Pharmaceuticals Company
	Wilmington, DE 19898 (US)

(72)	Inventors:
	RODGERS, James, David Landenberg, PA 19350 (US) LAM, Patrick, Yuk-Sun Chadds Ford, PA 19317 (US)

(74)	Representative: Pett, Christopher Phineas, et al
	Frank B. Dehn & Co., European Patent Attorneys, 179 Queen Victoria Street London EC4V 4EL London EC4V 4EL (GB)

(54)	(4R,5S,6S,7R)-HEXAHYDRO-1- 5-(3-AMINOINAZOLE)METHYL] -3-BUTYL-5,6-DIHYDROXY-4,7-BIS PHENYLMETHYL] -2H-1,3-DIAZEPIN-2-ONE, ITS PREPARATION AND ITS USE AS HIV PROTEASE INHIBITOR