(19)

(11)

EP 0 937 147 A1

(12)

(43) Date of publication: 25.08.1999 Bulletin 1999/34 (21) Application number: 97920102.0 (22) Date of filing: 03.04.1997

(51) International Patent Classification (IPC):  C07K 14/ 52( . ) A61K 38/ 00( . ) C12N 15/ 19( . ) (86) International application number: PCT/US1997/005570 (87) International publication number: WO 1997/037022 (09.10.1997 Gazette 1997/43)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 03.04.1996 US 19960014796P 03.04.1996 WO 1996US04456 (71) Applicant: HUMAN GENOME SCIENCES, INC. Rockville, MD 20850-3338 (US)	(72) Inventors: NI, Jian Rockville, MD 20853 (US) YU, Guo-Liang San Mateo, CA 94403 (US) GENTZ, Reiner, L. Silver Spring, MD 20904 (US) LI, Haodong Gaithersburg, MD 20878 (US) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 81634 München 81634 München (DE)