(19)

(11)

EP 0 937 247 A1

(12)

(43) Date of publication: 25.08.1999 Bulletin 1999/34 (21) Application number: 97946599.0 (22) Date of filing: 07.11.1997

(51) International Patent Classification (IPC):  A61K 9/ 00( . ) G01N 13/ 00( . ) G01N 33/ 15( . ) (86) International application number: PCT/US1997/020395 (87) International publication number: WO 1998/020340 (14.05.1998 Gazette 1998/19)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 07.11.1996 US 19960029885P (71) Applicant: ORTHO PHARMACEUTICAL CORPORATION Raritan, New Jersey 08869-0606 (US)	(72) Inventors: CORBO, Michael Flemington, NJ 08822 (US) DeGHETTO, Paul, Kevin Bound Brook, NJ 08805 (US) SCHULTZ, Thomas, William Richboro, PA 18954 (US) (74) Representative: Mercer, Christopher Paul  Carpmaels & Ransford 43, Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)