(19)
(11) EP 0 938 305 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
19.10.2005 Bulletin 2005/42

(45) Mention of the grant of the patent:
17.08.2005 Bulletin 2005/33

(21) Application number: 97911024.4

(22) Date of filing: 21.10.1997
(51) International Patent Classification (IPC)7: A61K 31/165, A61K 31/485, A61K 31/135, A61P 25/04
(86) International application number:
PCT/US1997/019075
(87) International publication number:
WO 1998/017268 (30.04.1998 Gazette 1998/17)

(54)

METHOD OF ALLEVIATING PAIN BY MEANS OF COMBINING TRAMADOL WITH AN NMDA ANTAGONIST

VERFAHREN ZUR ERLEICHTERUNG VON SCHMERZEN DURCH EINE KOMBINATION VON TRAMADOL UND EINEN NMDA-ANTAGONIST

PROCEDE DESTINE A SOULAGER DES DOULEURS PAR LA COMBINAISON DE TRAMADOL ET D'UN ANTAGONISTE DE NMDA

(84) Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 24.10.1996 US 736369
01.08.1997 US 904519

(43) Date of publication of application:
01.09.1999 Bulletin 1999/35

(73) Proprietor: Endo Pharmaceuticals Inc.
Chadds Ford, PA 19317 (US)

(72) Inventor:
  • CARUSO, Frank, S.
    Colts Neck, NJ 07722 (US)

(74) Representative: HOFFMANN EITLE 
Patent- und Rechtsanwälte Arabellastrasse 4
81925 München
81925 München (DE)


(56) References cited: : 
EP-A- 0 615 749
WO-A-96/06822
US-A- 5 516 803
 WO-A-93/17673
US-A- 5 336 691
   
  • PRICE ET AL: "Effects of the combined oral administration of NSAIDs and dextromethorphan on behavioral symptoms indicative of arthritic pain in rats" PAIN, vol. 68, no. 1, 1996, pages 119-127, XP002061724
  • LEHMANN: "Tramadol for the management of acute pain" DRUGS, vol. 47, no. S1, 1994, pages 19-32, XP002061725
  • SEFRIN: "Therapie des Akuten Schmerzes im rahmen der Notfallmedizin" NOTFALL MEDIZIN, vol. 23, no. 4, 1997, pages 148-156, XP002061726
  • LIPMAN: "Analgesic drugs for neuropathic and sympathetically maintained pain" CLINICS IN GERIATRIC MEDICINE - PAIN MANAGEMENT, vol. 12, no. 3, August 1996, pages 501-515, XP002061727
  • BESSON: "LA COMPLEXIT DES ASPECTS PHYSIOPHARMACOLOGIQUES DE LA DOULEUR" DRUGS, vol. 53, no. s2, - 1997 pages 1-9, XP002061728
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).