(19)

(11)

EP 0 938 340 A2

(12)

(43) Date of publication: 01.09.1999 Bulletin 1999/35 (21) Application number: 97929483.0 (22) Date of filing: 14.07.1997

(51) International Patent Classification (IPC):  A61K 47/ 48( . ) (86) International application number: PCT/IL1997/000239 (87) International publication number: WO 1998/002189 (22.01.1998 Gazette 1998/03)

(84) Designated Contracting States: AT BE DE ES FR GB IT NL SE (30) Priority: 14.07.1996 IL 19960118848 (71) Applicant: Bar Ilan University 52900 Ramat Gan (IL)	(72) Inventors: MARGEL, Shlomo 76210 Rehovot (IL) BURDYGIN, Irene 48590 Rosh Ha'ayin (IL) (74) Representative: Hedley, Nicholas James Matthew  Stephenson Harwood One, St. Paul's Churchyard London EC4M 8SH London EC4M 8SH (GB)