(19)

(11)

EP 0 938 566 A2

(12)

(43) Date of publication: 01.09.1999 Bulletin 1999/35 (21) Application number: 97934442.0 (22) Date of filing: 20.08.1997

(51) International Patent Classification (IPC):  C12N 9/ 02( . ) C12N 9/ 10( . ) C12N 9/ 04( . ) (86) International application number: PCT/DK1997/000336 (87) International publication number: WO 1998/007867 (26.02.1998 Gazette 1998/08)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 22.08.1996 US 19960701458 (71) Applicant: Bioteknologisk Institut 2970 Hoersholm (DK)	(72) Inventors: ARNAU, José DK-2900 Hellerup (DK) ISRAELSEN, Hans DK-3450 Alleroed (DK) VRANG, Astrid DK-280 Lyngby (DK) JOERGENSEN, Flemming DK-2800 Lyngby (DK) MADSEN, Soeren, Michael DK-2200 Copenhagen N (DK) (74) Representative: Plougmann, Vingtoft & Partners A/S  Sankt Annae Plads 11, P.O. Box 3007 1021 Copenhagen K 1021 Copenhagen K (DK)