(19)

(11)

EP 0 939 814 A1

(12)

(43) Date of publication: 08.09.1999 Bulletin 1999/36 (21) Application number: 97944671.0 (22) Date of filing: 20.10.1997

(51) International Patent Classification (IPC):  A01K 67/ 033( . ) C12N 9/ 10( . ) A61K 38/ 00( . ) A61K 48/ 00( . ) C07K 14/ 47( . ) C12N 15/ 12( . ) A61K 39/ 00( . ) (86) International application number: PCT/CA1997/000775 (87) International publication number: WO 1998/017793 (30.04.1998 Gazette 1998/17)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 21.10.1996 US 19960028398P (71) Applicant: HSC Research and Development Limited Partnership Toronto, Ontario M5G 1X8 (CA)

(72) Inventors: EGAN, Sean E, HSC Research and Development L.P. Toronto, Ontario MG5 1X8 (CA) COHEN, Brenda, L, HSC Research & Development L.P. Toronto, Ontario M5G 1X8 (CA) LIPSHITZ, Howard, D. HSC Res. and Development L.P. Toronto, Ontario M5G 1X8 (CA) PHILLIPS, Robert, A. HSC Research & Development LP Toronto, Ontario M5G 1X8 (CA) (74) Representative: Harding, Charles Thomas  D. Young & Co. 21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)