(19)
(11)
EP 0 941 080 A2
(12)
(43)
Date of publication:
15.09.1999
Bulletin 1999/37
(21)
Application number:
97949579.0
(22)
Date of filing:
19.11.1997
(51)
International Patent Classification (IPC):
C07D
233/
64
( . )
A61K
31/
18
( . )
A61K
31/
415
( . )
A61K
31/
42
( . )
A61K
31/
426
( . )
A61K
31/
4439
( . )
A61P
3/
10
( . )
A61P
27/
02
( . )
C07D
213/
34
( . )
C07D
401/
04
( . )
A61K
31/
10
( . )
A61K
31/
41
( . )
A61K
31/
4164
( . )
A61K
31/
425
( . )
A61K
31/
44
( . )
A61P
1/
04
( . )
A61P
15/
00
( . )
A61P
35/
04
( . )
C07D
231/
12
( . )
(86)
International application number:
PCT/US1997/021489
(87)
International publication number:
WO 1998/022101
(
28.05.1998
Gazette 1998/21)
(84)
Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
(30)
Priority:
19.11.1996
US 19960031404P
(71)
Applicant:
G.D. SEARLE & CO.
Chicago IL 60680-5110 (US)
(72)
Inventors:
MASFERRER, Jaime, L.
Ballwin, MO 63011 (US)
RAZ, Amiram
52503 Israel (IL)
(74)
Representative:
Beil, Hans Chr., Dr., et al
BEIL, WOLFF & BEIL, Rechtsanwälte, Postfach 80 01 40
65901 Frankfurt
65901 Frankfurt (DE)
(54)
METHOD OF USING CYCLOOXYGENASE-2 INHIBITORS AS ANTI-ANGIOGENIC AGENTS