(19)

(11)

EP 0 941 111 A1

(12)

(43) Date of publication: 15.09.1999 Bulletin 1999/37 (21) Application number: 97948148.0 (22) Date of filing: 03.11.1997

(51) International Patent Classification (IPC):  A61K 38/ 18( . ) A61K 45/ 00( . ) C07K 16/ 22( . ) G01N 33/ 15( . ) A61K 39/ 395( . ) A61P 13/ 12( . ) C12Q 1/ 68( . ) G01N 33/ 50( . ) (86) International application number: PCT/US1997/019891 (87) International publication number: WO 1998/019696 (14.05.1998 Gazette 1998/19)

(84) Designated Contracting States: BE CH DE ES FR GB IT LI NL (30) Priority: 05.11.1996 US 19960030342P (71) Applicant: SMITHKLINE BEECHAM CORPORATION Philadelphia Pennsylvania 19103 (US)	(72) Inventors: BROOKS, David, Patrick West Chester, PA 19380 (US) LAPING, Nicholas, James West Chester, PA 19380 (US) (74) Representative: Valentine, Jill Barbara  SmithKline Beecham plc Corporate Intellectual Property, Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)