(19)

(11)

EP 0 941 120 A1

(12)

(43) Date of publication: 15.09.1999 Bulletin 1999/37 (21) Application number: 97946428.0 (22) Date of filing: 31.10.1997

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) A61K 38/ 27( . ) A61K 39/ 395( . ) A61P 35/ 00( . ) C07K 5/ 00( . ) C07K 5/ 06( . ) C07K 5/ 068( . ) C07K 14/ 00( . ) A61K 38/ 22( . ) A61K 38/ 46( . ) A61K 47/ 48( . ) A61P 43/ 00( . ) C07K 5/ 02( . ) C07K 5/ 065( . ) C07K 7/ 00( . ) (86) International application number: PCT/US1997/019851 (87) International publication number: WO 1998/019705 (14.05.1998 Gazette 1998/19)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 05.11.1996 US 19960030367P (71) Applicant: BRISTOL-MYERS SQUIBB COMPANY Princeton, NJ 08543-4000 (US)	(72) Inventors: KING, Dalton Hamden, CT 06514 (US) FIRESTONE, Raymond, A. New Haven, CT 06511 (US) DUBOWCHIK, Gene, M. Middlefield, CT 06455 (US) (74) Representative: Thinat, Michel  Cabinet Weinstein, 20 Avenue de Friedland 75008 Paris 75008 Paris (FR)