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(11)

EP 0 941 368 A2

(12)

(43) Date of publication: 15.09.1999 Bulletin 1999/37 (21) Application number: 97947550.0 (22) Date of filing: 14.11.1997

(51) International Patent Classification (IPC):  G01N 33/ 50( . ) C12N 5/ 10( . ) C12N 15/ 09( . ) C12Q 1/ 68( . ) C07K 16/ 40( . ) C12N 9/ 64( . ) C12P 21/ 08( . ) G01N 33/ 574( . ) (86) International application number: PCT/US1997/020948 (87) International publication number: WO 1998/021365 (22.05.1998 Gazette 1998/20)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 14.11.1996 US 19960759354 (71) Applicants: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH Rochester, MN 55905 (US) HYBRITECH INCORPORATED San Diego, CA 92121 (US)

(72) Inventors: TINDALL, Donald, J. Rochester, MN 55901 (US) YOUNG, Charles, Y., F. Rochester, MN 55901 (US) MCCORMICK, Daniel, J. Rochester, MN 55904 (US) KLEE, George, G. Rochester, MN 55902 (US) SAEDI, Mohammad, Saeed San Diego, CA 92126 (US) KUMAR, Abhay San Diego, CA 92129 (US) RITTENHOUSE, Harry, G. Del Mar, CA 92014 (US) WOLFERT, Robert, L. San Diego, CA 92131 (US) (74) Representative: Beresford, Keith Denis Lewis, et al  BERESFORD & Co. High Holborn 2-5 Warwick Court London WC1R 5DJ London WC1R 5DJ (GB)