(19)
(11) EP 0 942 924 A2

(12)

(43) Date of publication:
22.09.1999 Bulletin 1999/38

(21) Application number: 97950601.0

(22) Date of filing: 21.11.1997
(51) International Patent Classification (IPC): 
A61K 38/ 00( . )
A61K 31/ 216( . )
A61P 25/ 28( . )
C07K 5/ 06( . )
C07K 5/ 065( . )
C07K 5/ 083( . )
 A61K 31/ 165( . )
A61K 38/ 55( . )
C07C 237/ 22( . )
C07K 5/ 062( . )
C07K 5/ 08( . )
C07K 5/ 087( . )
(86) International application number:
PCT/US1997/020804
(87) International publication number:
WO 1998/022494 (28.05.1998 Gazette 1998/21)
(84) Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 22.11.1996 US 19960755442
28.02.1997 US 19970808528
28.02.1997 US 19970807528
28.02.1997 US 19970807427

(71) Applicants:
  • Elan Pharmaceuticals, Inc.
    South San Francisco, CA 94080 (US)
  • ELI LILLY AND COMPANY
    Indianapolis, Indiana 46285 (US)

(72) Inventors:
  • AUDIA, James, E.
    Indianapolis, IN 46278 (US)
  • BRITTON, Thomas, C.
    Carmel, IN 46033 (US)
  • DROSTE, James, J.
    Indianapolis, IN 46254 (US)
  • FOLMER, Beverly, K.
    Newark, DE 19702 (US)
  • HUFFMAN, George, W.
    Carmel, IN 46032 (US)
  • JOHN, Varghese
    San Francisco, CA 94122 (US)
  • LATIMER, Lee, H.
    Oakland, CA 94618 (US)
  • MABRY, Thomas, E.
    Indianapolis, IN 46227 (US)
  • NISSEN, Jeffrey, S.
    Indianapolis, IN 46268 (US)
  • PORTER, Warren, J.
    Indianapolis, IN 46260 (US)
  • REEL, Jon, K.
    Carmel, IN 46032 (US)
  • THORSETT, Eugene, D.
    Moss Beach, CA 94038 (US)
  • TUNG, Jay, S.
    Belmont, CA 94002 (US)
  • WU, Jing
    San Mateo, CA 94402 (US)
  • EID, Clark, Norman
    Cheshire, CT 06410 (US)
  • SCOTT, William, Leonard
    Indianapolis, IN 46208 (US)

(74) Representative: Adams, Nicola, et al 
Abel & Imray, 20 Red Lion Street
London WC1R 4PQ
London WC1R 4PQ (GB)

   


(54) METHODS AND COMPOUNDS FOR INHIBITING $g(b)-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS