(19)
(11) EP 0 942 996 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
21.02.2007 Bulletin 2007/08

(45) Mention of the grant of the patent:
03.01.2007 Bulletin 2007/01

(21) Application number: 97948587.7

(22) Date of filing: 02.12.1997
(51) International Patent Classification (IPC): 
C12N 15/62(2006.01)
A61K 47/48(2006.01)
C12N 9/64(2006.01)
 A61K 51/08(2006.01)
A61K 38/48(2006.01)
(86) International application number:
PCT/US1997/021918
(87) International publication number:
WO 1998/024917 (11.06.1998 Gazette 1998/23)

(54)

THROMBOLYTIC AGENTS WITH ANTITHROMBOTIC ACTIVITY

THROMBOLYTISCHE SUBSTANZEN MIT ANTITHROMBOTISCHE AKTIVITÄT

AGENTS THROMBOLYTIQUES A ACTIVITE ANTITHROMBOTIQUE

(84) Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 02.12.1996 US 753781

(43) Date of publication of application:
22.09.1999 Bulletin 1999/38

(73) Proprietor: UNIVERSITY OF SOUTHERN CALIFORNIA
Los Angeles, CA 90089-2561 (US)

(72) Inventors:
  • MARKLAND, Francis, S., Jr.
    Manhattan Beach, CA 90266 (US)
  • BUSH, Larry, R.
    Exeter, NH 03833 (US)
  • SWENSON, Stephen
    Arcadia, CA 91007 (US)
  • FLORES SANCHEZ, Eladio
    CEP-30730-090 Belo Horizonte, MG (BR)

(74) Representative: Dörries, Hans Ulrich et al
Dörries Frank-Molnia Pohlman Postfach 22 16 61
80506 München
80506 München (DE)


(56) References cited: : 
WO-A-94/23758
US-A- 4 610 879
US-A- 5 328 898
 WO-A-95/25720
US-A- 5 086 069
   
  • HUA ZI-CHUN ET AL.: "Characterization of a recombinant chimeric plasminogen activator composed of Gly-Pro-Arg-Pro tetrapeptide and truncated urokinase-type plasminogen activator expressed in Escherichia coli." BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 222, no. 2, 15 May 1996, pages 576-583, XP002058508
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).