(19)

(11)

EP 0 944 403 A2

(12)

(43) Date of publication: 29.09.1999 Bulletin 1999/39 (21) Application number: 97953182.0 (22) Date of filing: 10.12.1997

(51) International Patent Classification (IPC):  A61L 27/ 00( . ) A61L 27/ 38( . ) A61L 31/ 14( . ) A61L 27/ 20( . ) A61L 27/ 52( . ) (86) International application number: PCT/US1997/022859 (87) International publication number: WO 1998/025653 (18.06.1998 Gazette 1998/24)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 10.12.1996 US 19960762733 27.06.1997 US 19970051084P 19.09.1997 US 19970059558P (71) Applicant: Reprogenesis, Inc Cambridge, MA 02139 (US)	(72) Inventors: BORLAND, Kermit, M. Shrewsbury, MA 01545 (US) ZHOU, Tao Dunham, NH 03824 (US) NELSON, Gordon, P. N. Attleboro, MA 02760 (US) OMSTEAD, Daniel R. Acton MA 07120 (US) (74) Representative: Lee, Nicholas John, et al  Kilburn & Strode, 20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)