N-(ARYL/HETEROARYL) AMINO ACID ESTERS, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS - Patent 0944580

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(11)

EP 0 944 580 A2

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(43)	Date of publication:
	29.09.1999 Bulletin 1999/39

(21)	Application number: 97952177.0

(22)	Date of filing: 20.11.1997

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International Patent Classification (IPC):

C07D 317/ 24^{( . )}
A61K 31/ 27^{( . )}
A61K 31/ 357^{( . )}
A61K 31/ 40^{( . )}
A61K 31/ 428^{( . )}
C07C 229/ 18^{( . )}
C07C 247/ 16^{( . )}
C07C 259/ 14^{( . )}
C07C 259/ 18^{( . )}
C07D 209/ 08^{( . )}
C07D 229/ 02^{( . )}
C07D 307/ 12^{( . )}
C07D 319/ 06^{( . )}
C07K 14/ 47^{( . )}

A61K 31/ 223^{( . )}
A61K 31/ 341^{( . )}
A61K 31/ 36^{( . )}
A61K 31/ 404^{( . )}
A61P 25/ 28^{( . )}
C07C 229/ 60^{( . )}
C07C 255/ 58^{( . )}
C07C 259/ 16^{( . )}
C07D 207/ 325^{( . )}
C07D 215/ 38^{( . )}
C07D 277/ 62^{( . )}
C07D 317/ 58^{( . )}
C07D 319/ 18^{( . )}

(86)	International application number:
	PCT/US1997/020356

(87)	International publication number:
	WO 1998/022441 (28.05.1998 Gazette 1998/21)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
	Designated Extension States:
	AL LT LV MK RO SI

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Priority:

22.11.1996 US 19960755444

(71)	Applicants:
	Elan Pharmaceuticals, Inc. South San Francisco, CA 94080 (US) ELI LILLY AND COMPANY Indianapolis, Indiana 46285 (US)

(72)	Inventors:
	AUDIA, James, E. Indianapolis, IN 46278 (US) FOLMER, Beverly, K. Newark, DE 19702 (US) JOHN, Varghese San Francisco, CA 94122 (US) LATIMER, Lee, H. Oakland, CA 94618 (US) NISSEN, Jeffrey, S. Indianapolis, IN 46268 (US) REEL, Jon, K. Carmel, IN 46032 (US) THORSETT, Eugene, D. Moss Beach, CA 94038 (US) WHITESITT, Celia, A. Greenwood, IN 46142 (US)

(74)	Representative: Adams, Nicola, et al
	Abel & Imray, 20 Red Lion Street London WC1R 4PQ London WC1R 4PQ (GB)

(54)	N-(ARYL/HETEROARYL) AMINO ACID ESTERS, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS