(19)

(11)

EP 0 944 620 A1

(12)

(43) Date of publication: 29.09.1999 Bulletin 1999/39 (21) Application number: 97948238.0 (22) Date of filing: 21.11.1997

(51) International Patent Classification (IPC):  A61K 31/ 4178( . ) A61P 9/ 00( . ) A61P 25/ 00( . ) A61P 27/ 16( . ) C07D 403/ 12( . ) A61P 1/ 00( . ) A61P 11/ 00( . ) A61P 27/ 02( . ) A61P 43/ 00( . ) (86) International application number: PCT/US1997/020551 (87) International publication number: WO 1998/023609 (04.06.1998 Gazette 1998/22)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 25.11.1996 US 19960031740P (71) Applicant: THE PROCTER & GAMBLE COMPANY Cincinnati, Ohio 45202 (US)

(72) Inventors: CUPPS, Thomas, Lee Oxford, OH 45056 (US) BOGDAN, Sophie, Eva Maineville, OH 45039 (US) HENRY, Raymond, Todd Pleasant Plain, OH 45162 (US) SHELDON, Russell, James Fairfield, OH 45014 (US) SEIBEL, William, Lee Hamilton, OH 45011 (US) ARES, Jeffrey, Joseph Hamilton, OH 45011 (US) (74) Representative: Clemo, Nicholas Graham, et al  Procter & Gamble Technical Centres Limited Patent Department Lovett House Lovett Road Staines, Middlesex TW18 3AZ Staines, Middlesex TW18 3AZ (GB)