(19)

(11)

EP 0 944 651 A2

(12)

(43) Date of publication: 29.09.1999 Bulletin 1999/39 (21) Application number: 97920293.0 (22) Date of filing: 09.04.1997

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 31/ 48( . ) A61P 35/ 00( . ) C07K 14/ 475( . ) C07K 16/ 32( . ) C12N 15/ 12( . ) C12Q 1/ 68( . ) A61K 48/ 00( . ) A61K 31/ 00( . ) A61K 38/ 00( . ) C07K 14/ 47( . ) C07K 14/ 82( . ) C12N 5/ 10( . ) C12P 21/ 08( . ) G01N 33/ 50( . ) (86) International application number: PCT/US1997/005930 (87) International publication number: WO 1997/038085 (16.10.1997 Gazette 1997/44)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 10.04.1996 US 19960015167P 05.06.1996 WO 1996US09286 06.06.1996 US 19960019202P 11.07.1996 US 19960678280 (71) Applicant: California Pacific Medical Center San Francisco, CA 94115 (US)	(72) Inventors: SMITH, Helene San Francisco, CA 94110 (US) CHEN, Ling-Chun Fremont, CA 94536 (US) (74) Representative: Goldin, Douglas Michael  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)