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EP 0 946 148 A2

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(43) Date of publication: 06.10.1999 Bulletin 1999/40 (21) Application number: 97945945.0 (22) Date of filing: 26.11.1997

(51) International Patent Classification (IPC):  A61K 9/ 127( . ) A61K 31/ 7088( . ) A61K 31/ 711( . ) A61K 31/ 708( . ) A61K 31/ 7105( . ) A61K 48/ 00( . ) (86) International application number: PCT/GB1997/003235 (87) International publication number: WO 1998/023260 (04.06.1998 Gazette 1998/22)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 26.11.1996 GB 19960024536 (71) Applicants: UNIVERSITY OF STRATHCLYDE Glasgow G1 1XQ (GB) UNIVERSITY OF EDINBURGH South Bridge, Edinburgh EH8 9YL (GB) COMMON SERVICES AGENCY Edinburgh EH5 3SE (GB)

(72) Inventors: CARTER, Katharine, Christine Edinburgh EH3 7DH (GB) MULLEN, Alexander, Balfour St. Leonards, East Kilbride G74 2HE (GB) BAILLIE, Alan, James Helensburgh G84 9HY (GB) ANSELL, John, Douglas Edinburgh EH3 6NG (GB) MURPHY, William, Gerard Dublin 6 (IE) SAMUEL, Kay Edinburgh EH3 9JY (GB) (74) Representative: Horner, Martin Grenville, et al  Cruikshank & Fairweather 19 Royal Exchange Square Glasgow G1 3AE Scotland Glasgow G1 3AE Scotland (GB)