(19)

(11)

EP 0 946 192 A1

(12)

(43) Date of publication: 06.10.1999 Bulletin 1999/40 (21) Application number: 97952292.0 (22) Date of filing: 05.12.1997

(51) International Patent Classification (IPC):  A61K 38/ 44( . ) A61K 48/ 00( . ) G01N 33/ 50( . ) (86) International application number: PCT/US1997/022292 (87) International publication number: WO 1998/024472 (11.06.1998 Gazette 1998/23)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 06.12.1996 US 19960031995P (71) Applicant: Powis, Garth Tucson, AZ 85750 (US)	(72) Inventor: Powis, Garth Tucson, AZ 85750 (US) (74) Representative: Lucas, Brian Ronald  Lucas & Co. 135 Westhall Road Warlingham Surrey CR6 9HJ Warlingham Surrey CR6 9HJ (GB)