(19)

(11)

EP 0 946 226 A1

(12)

(43) Date of publication: 06.10.1999 Bulletin 1999/40 (21) Application number: 97943964.0 (22) Date of filing: 02.10.1997

(51) International Patent Classification (IPC):  A61M 5/ 315( . ) (86) International application number: PCT/GB1997/002657 (87) International publication number: WO 1998/014230 (09.04.1998 Gazette 1998/14)

(84) Designated Contracting States: DE DK ES FR GB IT (30) Priority: 02.10.1996 GB 19960020513 (71) Applicants: OWEN MUMFORD LIMITED Woodstock, Oxford OX20 1TU (GB) ELI LILLY AND COMPANY Indianapolis, Indiana 46285 (US)	(72) Inventors: MARTEAU, Denis Oxford OX15 NZ (GB) YEAGER, Harold Indianapolis, IN 46256 (US) (74) Representative: Lainé, Simon James, et al  Wynne-Jones, Lainé & James 22, Rodney Road Cheltenham Gloucestershire GL50 1JJ Cheltenham Gloucestershire GL50 1JJ (GB)