(19)

(11)

EP 0 946 594 A2

(12)

(43) Date of publication: 06.10.1999 Bulletin 1999/40 (21) Application number: 97940809.0 (22) Date of filing: 04.09.1997

(51) International Patent Classification (IPC):  C07K 7/ 08( . ) A61K 38/ 00( . ) C07K 14/ 655( . ) (86) International application number: PCT/US1997/015578 (87) International publication number: WO 1998/009991 (12.03.1998 Gazette 1998/10)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV RO SI (30) Priority: 05.09.1996 US 19960025468P (71) Applicants: ZymoGenetics, Inc. Seattle, WA 98102 (US) THE UNIVERSITY OF WASHINGTON Seattle, WA 98195 (US)

(72) Inventors: ENSINCK, John, W. Seattle, WA 98112 (US) VOGEL, Robin, E. Vashon, WA 98070 (US) LASCHANSKY, Ellen, C. Seattle, WA 98102 (US) FRANCIS, Bruce, H. Seattle, WA 98112 (US) BASKIN, Denis, G. Redmond, WA 98052 (US) D'ALESSIO, David, A. Seattle, WA 98103 (US) HOFFMAN, Ross, C. Seattle, WA 98102 (US) (74) Representative: Glawe, Delfs, Moll & Partner  Patentanwälte Rothenbaumchaussee 58 20148 Hamburg 20148 Hamburg (DE)