(19)

(11)

EP 0 948 330 A1

(12)

(43) Date of publication: 13.10.1999 Bulletin 1999/41 (21) Application number: 97937142.0 (22) Date of filing: 06.08.1997

(51) International Patent Classification (IPC):  C07D 223/ 16( . ) A61K 31/ 44( . ) A61P 25/ 28( . ) A61P 43/ 00( . ) C07D 235/ 04( . ) C07D 333/ 54( . ) A61K 31/ 4184( . ) A61K 31/ 55( . ) A61P 29/ 00( . ) C07D 213/ 74( . ) C07D 235/ 06( . ) (86) International application number: PCT/US1997/013858 (87) International publication number: WO 1998/005328 (12.02.1998 Gazette 1998/06)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 06.08.1996 US 19960023802P (71) Applicant: SMITHKLINE BEECHAM CORPORATION Philadelphia Pennsylvania 19103 (US)	(72) Inventors: WIDDOWSON, Katherine, L. King of Prussia, PA 19406 (US) GLEASON, John, Gerald Downingtown, PA 19335 (US) (74) Representative: Blakey, Alison Jane, et al  Smithkline Beecham, Corporate Intellectual Property, Two New Horizons Court Brentford, Middlesex, TW8 9EP Brentford, Middlesex, TW8 9EP (GB)