(19)

(11)

EP 0 948 331 A2

(12)

(43) Date of publication: 13.10.1999 Bulletin 1999/41 (21) Application number: 97953042.0 (22) Date of filing: 03.12.1997

(51) International Patent Classification (IPC):  C07D 239/ 47( . ) A61K 31/ 506( . ) A61K 31/ 505( . ) A61K 31/ 513( . ) (86) International application number: PCT/US1997/021402 (87) International publication number: WO 1998/025596 (18.06.1998 Gazette 1998/24)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 12.12.1996 US 19960032648P (71) Applicant: PHARMACIA & UPJOHN COMPANY Kalamazoo, Michigan 49001 (US)	(72) Inventors: BUXSER, Stephen, E. Kalamazoo, MI 49008 (US) FITZPATRICK, Francis, A. Salt Lake City, UT 84103 (US) (74) Representative: Perry, Robert Edward  GILL JENNINGS & EVERY Broadgate House 7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)