(19)

(11)

EP 0 948 347 A1

(12)

(43) Date of publication: 13.10.1999 Bulletin 1999/41 (21) Application number: 97934090.0 (22) Date of filing: 16.07.1997

(51) International Patent Classification (IPC):  C07K 14/ 00( . ) A61K 38/ 00( . ) C07K 14/ 415( . ) (86) International application number: PCT/US1997/011997 (87) International publication number: WO 1999/003492 (28.01.1999 Gazette 1999/04)

(84) Designated Contracting States: CH DE FR GB LI (71) Applicant: Chen, Sophie Millwood, NY 10547 (US)	(72) Inventors: CHEN, Sophie Millwood, NY 10547 (US) WANG, Xuhui Shangai (CN) (74) Representative: Bryer, Kenneth Robert, et al  K.R. Bryer & Co. 7 Gay Street Bath BA1 2PH Bath BA1 2PH (GB)