(19)

(11)

EP 0 948 352 A1

(12)

(43) Date of publication: 13.10.1999 Bulletin 1999/41 (21) Application number: 97953919.0 (22) Date of filing: 22.12.1997

(51) International Patent Classification (IPC):  A61K 39/ 118( . ) A61P 15/ 00( . ) A61K 39/ 39( . ) A61P 31/ 04( . ) (86) International application number: PCT/EP1997/007282 (87) International publication number: WO 1998/028005 (02.07.1998 Gazette 1998/26)

(84) Designated Contracting States: BE CH DE ES FR GB IT LI NL (30) Priority: 24.12.1996 GB 19960026864 (71) Applicant: SmithKline Beecham Biologicals s.a. 1330 Rixensart (BE)	(72) Inventors: MAISONNEUVE, Jean-Francois, Lucien Gaithersburg, MD 20879 (US) VERLANT, Vincent, Georges, Christian, Louis Rue de l'Institut 89,B-1330 Rixensart (BE) (74) Representative: Dalton, Marcus Jonathan William, et al  SmithKline Beecham plc Corporate Intellectual Property, Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)