SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE - Patent 0948497

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EP 0 948 497 A2

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(43)	Date of publication:
	13.10.1999 Bulletin 1999/41

(21)	Application number: 97954778.0

(22)	Date of filing: 04.12.1997

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International Patent Classification (IPC):

C07D 239/ 42^{( . )}
A61K 31/ 513^{( . )}
A61P 1/ 04^{( . )}
A61P 3/ 10^{( . )}
A61P 9/ 10^{( . )}
A61P 11/ 16^{( . )}
A61P 17/ 06^{( . )}
A61P 19/ 06^{( . )}
A61P 19/ 10^{( . )}
A61P 25/ 00^{( . )}
A61P 25/ 28^{( . )}
A61P 29/ 00^{( . )}
A61P 35/ 00^{( . )}
A61P 37/ 06^{( . )}
C07D 401/ 04^{( . )}
C07D 405/ 14^{( . )}
C07D 417/ 12^{( . )}
C07D 487/ 04^{( . )}

A61K 31/ 506^{( . )}
A61K 31/ 5377^{( . )}
A61P 1/ 18^{( . )}
A61P 7/ 00^{( . )}
A61P 11/ 00^{( . )}
A61P 17/ 00^{( . )}
A61P 19/ 02^{( . )}
A61P 19/ 08^{( . )}
A61P 21/ 00^{( . )}
A61P 25/ 04^{( . )}
A61P 27/ 16^{( . )}
A61P 31/ 12^{( . )}
A61P 35/ 02^{( . )}
A61P 37/ 08^{( . )}
C07D 401/ 14^{( . )}
C07D 409/ 14^{( . )}
C07D 417/ 14^{( . )}

(86)	International application number:
	PCT/US1997/022390

(87)	International publication number:
	WO 1998/024782 (11.06.1998 Gazette 1998/23)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
	Designated Extension States:
	AL LT LV MK RO SI

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Priority:

05.12.1996 US 19960032128P
13.06.1997 US 19970050950P
21.11.1997 US 19970976054

(60)	Divisional application:
	02027704.2 / 1314731

(60)	Divisional application:
	02027705.9 / 1314732

(71)	Applicant: Amgen inc.
	Thousand Oaks, CA 91360 (US)

(72)	Inventors:
	SPOHR, Ulrike, D. Boulder, CO 80301 (US) MALONE, Michael, J. Boulder, CO 80301 (US) MANTLO, Nathan, B. Lafayette, CO 80026 (US)

(74)	Representative: Richardson, Kate, et al
	Forrester & Boehmert, Franz-Joseph Strasse 38 80801 München 80801 München (DE)

(54)	SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE