(19)

(11)

EP 0 948 508 A1

(12)

(43) Date of publication: 13.10.1999 Bulletin 1999/41 (21) Application number: 97946877.0 (22) Date of filing: 31.10.1997

(51) International Patent Classification (IPC):  G01N 33/ 50( . ) A61K 39/ 395( . ) A61P 31/ 12( . ) C07K 14/ 035( . ) C12N 1/ 15( . ) C12N 1/ 21( . ) C12N 15/ 09( . ) C12P 21/ 08( . ) G01N 33/ 15( . ) A61K 39/ 00( . ) A61K 38/ 00( . ) A61K 48/ 00( . ) A61P 31/ 22( . ) C07K 16/ 08( . ) C12N 1/ 19( . ) C12N 5/ 10( . ) C12P 21/ 02( . ) C12Q 1/ 68( . ) G01N 33/ 566( . ) (86) International application number: PCT/US1997/020016 (87) International publication number: WO 1998/020016 (14.05.1998 Gazette 1998/19)

(84) Designated Contracting States: BE CH DE DK FR GB IT LI NL (30) Priority: 04.11.1996 US 19960030279P 09.06.1997 US 19970049018P (71) Applicants: SMITHKLINE BEECHAM CORPORATION Philadelphia Pennsylvania 19103 (US) Sutton, David Wayne, PA 19087 (US)

(72) Inventors: ESSER, Klaus, Max Downingtown, PA 19335 (US) CHAN, John, Y. King of Prussia, PA 19406 (US) DABROWSKI-AMARAL, Christine, Ellen Parkesburg, PA 19365 (US) DELVECCHIO, Alfred, Michael West Chester, PA 19380 (US) DILLON, Susan, B. Chester Springs, PA 19425 (US) LEARY, Jeffrey, Joseph Wayne, PA 19087 (US) SUTTON, David Wayne, PA 19087 (US) (74) Representative: Mallalieu, Catherine Louise, et al  D. Young & Co., 21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)