(19)

(11)

EP 0 948 608 A1

(12)

(43) Date of publication: 13.10.1999 Bulletin 1999/41 (21) Application number: 97910269.0 (22) Date of filing: 30.10.1997

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C11B 3/ 00( . ) C12N 9/ 18( . ) A23J 7/ 00( . ) C12N 1/ 14( . ) C12R 1/ 645( . ) (86) International application number: PCT/DK1997/000490 (87) International publication number: WO 1998/018912 (07.05.1998 Gazette 1998/18)

(84) Designated Contracting States: BE CH DE ES FR GB IT LI NL SE (30) Priority: 31.10.1996 DK 19960001215 (71) Applicant: NOVO NORDISK A/S 2880 Bagsvaerd (DK)	(72) Inventors: HASIDA, Miyoko Urayasu-shi, Chiba-ken 279 (JP) TSUTSUMI, Noriko Ichikawa-shi, Chiba-ken 272 (JP) HALKIER, Torben DK-3460 Birkeroed (DK) STRINGER, Mary, Ann DK-2100 Koebenhavn (DK) (74) Representative: Jensen, Bo Hammer, et al  c/o Novo Nordisk A/S Novo Allé 2880 Bagsvaerd 2880 Bagsvaerd (DK)