(19)

(11)

EP 0 951 298 A1

(12)

(43) Date of publication: 27.10.1999 Bulletin 1999/43 (21) Application number: 97950306.0 (22) Date of filing: 22.12.1997

(51) International Patent Classification (IPC):  A61K 38/ 17( . ) G01N 33/ 68( . ) A61K 38/ 18( . ) (86) International application number: PCT/GB1997/003519 (87) International publication number: WO 1998/028006 (02.07.1998 Gazette 1998/26)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE (30) Priority: 23.12.1996 GB 19960026702 27.08.1997 US 19970057055P (71) Applicant: CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LIMITED Cambridge CB2 1TS (GB)	(72) Inventors: CHARNOCK-JONES, David, Stephen Cambridge CB2 2QZ (GB) SMITH, Stephen, Kevin Cambridge CB4 3AG (GB) CLARK, Dawn, Elizabeth Gore (NZ) (74) Representative: Lipscombe, Martin John  Keith W Nash & Co, Pearl Assurance House, 90-92 Regent Street Cambridge CB2 1DP Cambridge CB2 1DP (GB)