(19)

(11)

EP 0 951 544 A2

(12)

(43) Date of publication: 27.10.1999 Bulletin 1999/43 (21) Application number: 97940534.0 (22) Date of filing: 02.07.1997

(51) International Patent Classification (IPC):  A61K 48/ 00( . ) C07K 14/ 61( . ) C07K 14/ 745( . ) C07K 14/ 81( . ) C12N 9/ 64( . ) C12N 15/ 867( . ) C07K 14/ 56( . ) C07K 14/ 705( . ) C07K 14/ 755( . ) C12N 9/ 12( . ) C12N 15/ 12( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1997/011784 (87) International publication number: WO 1998/000541 (08.01.1998 Gazette 1998/01)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 03.07.1996 US 19960645601 13.08.1996 US 19960696381 04.06.1997 US 19970869309 (71) Applicant: CHIRON CORPORATION Emeryville, California 94608 (US)

(72) Inventors: JOLLY, Douglas, J. Leucadia, CA 92024 (US) BARBER, Jack, R. San Diego, CA 92129 (US) CHANG, Stephen, M., W. Poway, CA 92064 (US) RESPESS, James, G. San Diego, CA 92109 (US) ALLEN, John, R. San Diego, CA 92129 (US) BODER, Mordechai San Diego, CA 92104 (US) CHONG, Kimberly San Diego, CA 92128 (US) DE LA VEGA, Dan, Jr. San Diego, CA 92103 (US) DePOLO, Nicholas, J. Solano Beach, CA 92075 (US) HSU, David, Chi-Tang San Diego, CA 92122 (US) IBANEZ, Carlos, E. San Diego, CA 92129 (US) MITTELSTAEDT, Denice, M. San Diego, CA 92129 (US) PRUSSAK, Charles, E. San Diego, CA 92124 (US) GREENGARD, Judith San Diego, CA 92126 (US) LEE, Robert Carlsbad, CA 92009 (US) (74) Representative: Irvine, Jonquil Claire  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)