(19)

(11)

EP 0 951 549 A1

(12)

(43) Date of publication: 27.10.1999 Bulletin 1999/43 (21) Application number: 97944422.0 (22) Date of filing: 02.10.1997

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C07K 16/ 24( . ) C12N 1/ 15( . ) C12N 1/ 21( . ) C12N 15/ 19( . ) C07K 14/ 52( . ) C07K 19/ 00( . ) C12N 1/ 19( . ) C12N 5/ 10( . ) C12P 21/ 02( . ) (86) International application number: PCT/US1997/017122 (87) International publication number: WO 1998/014581 (09.04.1998 Gazette 1998/14)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE Designated Extension States: LT LV RO (30) Priority: 02.10.1996 US 19960027242P 09.10.1996 US 19960028042P 28.08.1997 US 19970058007P (71) Applicant: SCHERING CORPORATION Kenilworth, New Jersey 07033-0530 (US)	(72) Inventors: HEDRICK, Joseph, A. Sunnyvale, CA 94086 (US) ZLOTNIK, Albert Palo Alto, CA 94306 (US) (74) Representative: Ritter, Stephen David, et al  Mathys & Squire 100 Grays Inn Road London WC1X 8AL London WC1X 8AL (GB)