(19)

(11)

EP 0 951 551 A2

(12)

(43) Date of publication: 27.10.1999 Bulletin 1999/43 (21) Application number: 97952609.0 (22) Date of filing: 22.12.1997

(51) International Patent Classification (IPC):  G01N 33/ 50( . ) A61K 39/ 395( . ) A61P 37/ 02( . ) C07K 14/ 525( . ) C07K 14/ 715( . ) C07K 16/ 28( . ) C12N 1/ 19( . ) C12N 5/ 06( . ) C12N 5/ 20( . ) C12N 15/ 11( . ) C12N 15/ 19( . ) C12P 21/ 02( . ) C12Q 1/ 02( . ) G01N 33/ 566( . ) A61K 38/ 00( . ) A61P 29/ 00( . ) C07K 14/ 52( . ) C07K 14/ 705( . ) C07K 16/ 24( . ) C12N 1/ 15( . ) C12N 1/ 21( . ) C12N 5/ 10( . ) C12N 15/ 09( . ) C12N 15/ 12( . ) C12N 15/ 62( . ) C12P 21/ 08( . ) G01N 33/ 15( . ) (86) International application number: PCT/US1997/023775 (87) International publication number: WO 1998/028426 (02.07.1998 Gazette 1998/26)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 23.12.1996 US 19960059978P 07.03.1997 US 19970077181P 14.10.1997 US 19970064671P (60) Divisional application: 08010882.2 / 2003203 (60) Divisional application: 10182863.0 / 2314695 (71) Applicant: IMMUNEX CORPORATION Seattle Washington 98101 (US)	(72) Inventors: ANDERSON, Dirk, M. Seattle, WA 98107 (US) GALIBERT, Laurent, J. Seattle, WA 98119 (US) MARASKOVSKY, Eugene Seattle, WA 98103 (US) (74) Representative: Cornish, Kristina Victoria Joy, et al  Kilburn & Strode, 20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)