(19)

(11)

EP 0 951 564 A1

(12)

(43) Date of publication: 27.10.1999 Bulletin 1999/43 (21) Application number: 97910545.0 (22) Date of filing: 30.10.1997

(51) International Patent Classification (IPC):  G01N 33/ 50( . ) C07K 14/ 72( . ) C12Q 1/ 68( . ) C07K 14/ 575( . ) C12N 15/ 00( . ) G01N 33/ 15( . ) (86) International application number: PCT/GB1997/002988 (87) International publication number: WO 1998/020158 (14.05.1998 Gazette 1998/19)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: SI (30) Priority: 01.11.1996 GB 19960022866 01.11.1996 GB 19960022867 01.11.1996 GB 19960022865 01.11.1996 GB 19960022869 01.11.1996 GB 19960022847 01.11.1996 GB 19960022849 01.11.1996 GB 19960022851 01.11.1996 GB 19960022870 01.11.1996 GB 19960022868 01.11.1996 GB 19960022848 01.11.1996 GB 19960022850 (71) Applicant: SMITHKLINE BEECHAM PLC Brentford, Middlesex TW8 9EP (GB)

(72) Inventor: BEELEY, Lee James, SmithKline Beecham Pharma. Harlow, Essex CM19 5AW (GB) (74) Representative: Rutter, Keith, Dr., et al  SmithKline Beecham plc Corporate Intellectual Property, Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)