| (19) |
 |
|
(11) |
EP 0 952 225 A3 |
| (12) |
EUROPEAN PATENT APPLICATION |
| (88) |
Date of publication A3: |
|
02.08.2000 Bulletin 2000/31 |
| (43) |
Date of publication A2: |
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27.10.1999 Bulletin 1999/43 |
| (22) |
Date of filing: 11.02.1999 |
|
|
| (84) |
Designated Contracting States: |
|
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
Designated Extension States: |
|
AL LT LV MK RO SI |
| (30) |
Priority: |
13.02.1998 JP 3185798
13.02.1998 JP 3185898
|
| (71) |
Applicant: Nippon Shokubai Co., Ltd. |
|
Osaka-shi, Osaka 541-0043 (JP) |
|
| (72) |
Inventors: |
|
- Mukouyama, Masaharu
Tsukuba-gun, Ibaraki 300-2301 (JP)
- Komatsuzaki, Satomi
Nishiibaraki-gun, Ibaraki 319-0200 (JP)
|
| (74) |
Representative: Harding, Charles Thomas |
|
D. Young & Co. 21 New Fetter Lane
London EC4A 1DA
London EC4A 1DA (GB) |
|
| |
|
| (54) |
Process for production of l-aspartic acid from fumaric acid with aspartase |
(57) A process for producing crystalline L-aspartic acid is disclosed which essentially
consisting of the steps of preparing a mix solution containing fumaric acid, ammonia
and an alkaline metal hydroxide, reacting the mix solution with aspartase to give
a reaction solution containing L-aspartate and crystallizing L-aspartic acid out of
the reaction solution, wherein a further amount of ammonia is added to the reaction
solution containing L-aspartate and subsequently fumaric acid is added thereto to
crystallize L-aspartic acid. The process can provide crystalline L-aspartic acid of
high purity in a good workability without the need of any complicated steps