(19)

(11)

EP 0 952 834 A2

(12)

(43) Date of publication: 03.11.1999 Bulletin 1999/44 (21) Application number: 97921954.0 (22) Date of filing: 12.05.1997

(51) International Patent Classification (IPC):  C07K 16/ 40( . ) C12Q 1/ 533( . ) C12Q 1/ 48( . ) (86) International application number: PCT/GB1997/001302 (87) International publication number: WO 1997/043437 (20.11.1997 Gazette 1997/50)

(84) Designated Contracting States: AT BE CH DE ES FR GB IE IT LI NL SE (30) Priority: 15.05.1996 GB 19960010174 25.04.1997 GB 19970008329 (71) Applicant: The University of Sheffield Sheffield, South Yorkshire S10 2UH (GB)	(72) Inventors: BROWN, Richard, John Sheffield S10 1HE (GB) WATTS, Donald, Jeremy Sheffield S10 5BS (GB) RUSSEL, Robert, Graham, Goodwin Sheffield S6 6GH (GB) ROGERS, Michael, John, University of Sheffield Sheffield S10 2RX (GB) (74) Representative: Price, Vincent Andrew  FRY HEATH & SPENCE The Old College 53 High Street Horley Surrey RH6 7BN Horley Surrey RH6 7BN (GB)