(19)

(11)

EP 0 952 841 A1

(12)

(43) Date of publication: 03.11.1999 Bulletin 1999/44 (21) Application number: 95929378.0 (22) Date of filing: 04.08.1995

(51) International Patent Classification (IPC):  A61K 47/ 48( . ) (86) International application number: PCT/US1995/009870 (87) International publication number: WO 1996/004001 (15.02.1996 Gazette 1996/08)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 05.08.1994 US 19940286327 07.06.1995 US 19950487693 (71) Applicant: MOLECULAR/STRUCTURAL BIOTECHNOLOGIES, INC. Bethesda, MD 20814 (US)	(72) Inventors: KATZ, Robert Gaithersburg, MD 20878 (US) TOMOAIA-COTISEL, Maria Rockville, MD 20852 (US) (74) Representative: Daniels, Jeffrey Nicholas, et al  Page White & Farrer 54 Doughty Street London WC1N 2LS London WC1N 2LS (GB)